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preamble_1704

LC50 for acute toxicity on inhalation is that concentration of vapour, mist or dust which, administered by continuous inhalation to both male and female young adult albino rats for one hour, is most likely to cause death within 14 days in one half of the animals tested. A solid substance shall be tested if at least 10 % (by mass) of its total mass is likely to be dust in a respirable range, e.g. the aerodynamic diameter of that particle-fraction is 10 μm or less. A liquid substance shall be tested if a mist is likely to be generated in a leakage of the transport containment. Both for solid and liquid substances more than 90 % (by mass) of a specimen prepared for inhalation toxicity shall be in the respirable range as defined above. The result is expressed in milligrams per litre of air for dusts and mists or in millilitres per cubic metre of air (parts per million) for vapours.

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Source: EUR-Lex (Cellar) · retrieved 2026-10-31 · Text as adopted (Official Journal); later amendments are not incorporated in this text.