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5. Low-risk active substances

An active substance shall not be considered of low risk where it is or has to be classified in accordance with Regulation (EC) No 1272/2008 as at least one of the following: carcinogenic, mutagenic, toxic to reproduction, sensitising chemicals, very toxic or toxic, explosive, corrosive. It shall also not be considered as of low risk if: persistent (half-life in soil is more than 60 days), bioconcentration factor is higher than 100, it is deemed to be an endocrine disrupter, or it has neurotoxic or immunotoxic effects.

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Source: EUR-Lex (Cellar) · retrieved 2026-10-29 · Text as adopted (Official Journal); later amendments are not incorporated in this text.