1. Conditions for comparative assessment

Where refusal or withdrawal of an authorisation of a plant protection product in favour of an alternative plant protection product or a non-chemical control or prevention method is considered, referred to as ‘substitution’, the alternative must, in the light of scientific and technical knowledge, show significantly lower risk to health or the environment. An assessment of the alternative shall be performed to demonstrate whether it can be used with similar effect on the target organism and without significant economic and practical disadvantages to the user or not. Further conditions for refusal or withdrawal of an authorisation are as follows: substitution shall be applied only where other methods or the chemical diversity of the active substances is sufficient to minimise the occurrence of resistance in the target organism; substitution shall be applied only to plant protection products where their use presents a significantly higher level of risk to human health or the environment; and substitution shall be applied only after allowing for the possibility, where necessary, of acquiring experience from use in practice, where not already available.

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Source: EUR-Lex (Cellar) · retrieved 2026-10-29 · Text as adopted (Official Journal); later amendments are not incorporated in this text.