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8.13.2. Neurotoxicity including developmental neurotoxicity The preferred test species is the rat unless another test species is justified to be more appropriate For delayed neurotoxicity tests the preferred species will be the adult hen If anticholinesterase activity is detected a test for response to reactivating agents should be considered If the active substance is an organophosphorus compound or if there is any evidence e.g. knowledge of the mechanism of action or from repeat dose studies that the active substance may have neurotoxic or developmental neurotoxic properties then additional information or specific studies will be required. For evaluation of consumer safety of active substances that may end up in food or feed, it is necessary to conduct toxicity studies by the oral route ADS

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Source: EUR-Lex (Cellar) · retrieved 2026-10-29 · Text as adopted (Official Journal); later amendments are not incorporated in this text.